Bromoacetonitrile: A Versatile Intermediate in Organic Synthesis

In the dynamic world of organic synthesis, intermediates play a critical role in the development of high-performance chemicals. One such compound that stands out for its reactivity and broad applicability is bromoacetonitrile. Known for its use in pharmaceuticals, agrochemicals, and fine chemicals, bromoacetonitrile is valued for its ability to act as a reactive halogenated nitrile in various synthetic processes.
In this blog, we’ll explore the structure, properties, applications, safety, and sourcing considerations related to bromoacetonitrile, and why it is an essential building block for modern chemistry.
What is Bromoacetonitrile?
Bromoacetonitrile is an organic compound with the molecular formula C2H2BrN. It consists of a bromine atom and a nitrile group attached to a methylene bridge. This combination offers significant chemical reactivity, making the compound useful in numerous organic transformations.
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Chemical Name: Bromoacetonitrile
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Molecular Formula: C2H2BrN
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CAS Number: 590-17-0
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Molecular Weight: 120.95 g/mol
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Appearance: Clear to light yellow liquid
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Odor: Sharp, pungent odor
Key Properties of Bromoacetonitrile
Property | Value |
---|---|
Appearance | Colorless to pale yellow liquid |
Boiling Point | 100–103 °C |
Density | 1.6 g/cm³ |
Solubility | Slightly soluble in water; soluble in organic solvents |
Purity | Typically > 98% (for industrial applications) |
These properties make bromoacetonitrile a highly reactive and useful intermediate for further functional group transformations.
Applications of Bromoacetonitrile
1. Pharmaceutical Industry
One of the most important uses of bromoacetonitrile is in the synthesis of active pharmaceutical ingredients (APIs). It acts as a starting material or intermediate for producing various therapeutic agents, especially those involving nitrile-containing heterocyclic structures.
2. Agrochemicals
Bromoacetonitrile is widely utilized in the manufacture of herbicides, insecticides, and fungicides. Its functional groups allow for further chemical modification, which helps in developing highly active agrochemical compounds that are both effective and selective.
3. Organic Synthesis
In research laboratories and industrial synthesis processes, bromoacetonitrile is used in alkylation, substitution, and condensation reactions. Its halogen and nitrile functionalities make it highly versatile for the formation of carbon-nitrogen and carbon-carbon bonds.
4. Fine Chemical Manufacturing
It is also employed in producing dyes, fragrances, and specialty chemicals. The presence of the nitrile group contributes to the development of compounds with strong electron-withdrawing characteristics, enhancing the reactivity of the final products. Benzyl chloromethyl ether is commonly used as a protecting agent for alcohol groups in organic synthesis.
Safety and Handling Precautions
Although bromoacetonitrile is a valuable chemical intermediate, it is considered toxic and must be handled with care.
Handling Guidelines
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Always use in a well-ventilated area or under a chemical fume hood.
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Wear protective clothing, gloves, and safety goggles.
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Avoid inhalation or direct skin contact.
Storage Recommendations
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Store in tightly closed containers.
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Keep in a cool, dry, and well-ventilated area, away from incompatible substances like strong bases and oxidizers.
Disposal
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Follow local environmental and chemical waste regulations.
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Use approved disposal methods for hazardous organic compounds.
Always consult the Material Safety Data Sheet (MSDS) before working with bromoacetonitrile.
Why Choose a Reliable Bromoacetonitrile Manufacturer?
When sourcing chemicals like bromoacetonitrile, quality, purity, and consistency are critical. A reputable manufacturer ensures that the compound meets industry standards and regulatory compliance for pharmaceutical and industrial use.
At Lifechem Pharma, we provide high-purity bromoacetonitrile to clients across India, Europe, and beyond. Our production follows strict quality control measures, and we deliver products with complete documentation and global shipping support.
Benefits of sourcing from Lifechem Pharma:
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Consistent product quality
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Competitive pricing
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Timely delivery
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Technical support and regulatory compliance
Conclusion
Bromoacetonitrile is a key compound in organic synthesis, serving industries ranging from pharmaceuticals to agrochemicals. Its reactive nature and dual functional groups make it an essential building block in the creation of advanced chemical structures. However, its handling requires care, and sourcing from a trusted supplier is crucial for safety and performance.
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